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In vitro , NLRP3 inflammasome activation in hUC-MSCs inhibits IL-1 and TNF- production by M1 macrophages, suppresses T cell proliferation, significantly reduces IFN- production by Th1 cells, slightly inhibits IL-4 production by Th2 cells, and promotes IL-10 production by T lymphocytes, without modulating Treg cell activity (277)

Kastenmller are co-inventors (through Duke University/Helmholtz Zentrum Mnchen) on patents on applications of metabolomics in diseases of the central nervous system and hold equity in Chymia LLC and IP in PsyProtix and Atai that are exploring the potential for therapeutic applications targeting mitochondrial metabolism in treatment-resistant depression