Caspase-8 Polyclonal Antibody, 20ul[BT-AP07124] Plasmid Preparation This membrane-associated| cytoplasmic protein functions

This membrane-associated| cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells

where it binds OGF and is translocated into the nucleus

Defects in CLCN7 are the cause of osteopetrosis autosomal recessive type 4 (OPTB4)

an autosomal recessive disease associated with a susceptibility to pyogenic infections

Caspase-8 Polyclonal Antibody, 20ul[BT-AP07124] Plasmid Preparation This membrane-associated| cytoplasmic protein functionsThis gene encodes a member of the cysteine aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large