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The MHRA states that these medicines are licensed to treat specific medical disorders and should not be used if you are not overweight or diabetic or want to lose weight for aesthetic or cosmetic purposes

This is in large part because of the inconsistency of who gets it

However many antidepressants inhibit CYP2D6 to various extents, which can interfere with the conversion of tamoxifen to endoxifen 49, 50,51 (see diagram)