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Carnitine transporter mutations in Crohn's disease consists of missense mutation(s) in the gene coding plasma membrane transporter OCTN1 (SLC22A4) and/or mutation(s) in the promoter of the gene encoding OCTN2 (SLC22A5) [14, 35]

This is a documented research concern, and it is one reason RUO framing is emphasised

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Clin Neurol Neurosurg 115(Suppl 1):S86-89 Lim EJ, Ahn YC, Jang ES, Lee SW, Lee SH, Son CG (2020) Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)