T-5224 Catalog No.:M8650-2 6-tetrahydro-3a

6-tetrahydro-3a

Epub 2014 Nov 21

thus indicating a potential application of SAE inhibitors in treating MYC-amplified tumors

InChi: InChI=1S/C26H34ClN6O2P/c1-32(2)18-12-14-33(15-13-18)19-10-11-21(23(16-19)35-3)30-26-28-17-20(27)25(31-26)29-22-8-6-7-9-24(22)36(4

T-5224 Catalog No.:M8650-2 6-tetrahydro-3aT 5224 is a selective inhibitor of c Fos activator protein 1. T 5224 ameliorates liver injury and improves survival through decreasing production of proinflammatory cytokines and chemokines in endotoxemic mice. T 5224 has been investigated in phase II human clinical trials. T 5224 may be a promising new treatment for septic kidney injury. Activator protein 1 (AP 1) is a pivotal transcription factor that regulates a wide range of cellular processes