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SIRM studies track metabolic transformations using stable isotope labeling and analyze the metabolic products using nuclear magnetic resonance (NMR) and mass spectrometry (MS) at different time points

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This trial used two animal models of MS: the experimental autoimmune encephalomyelitis, EAE, model to mimic the autoimmune response and neurodegeneration in MS and the cuprizone, CPZ, model to mimic demyelination to nerve cells and to study remyelination of the damaged nerve cells in MS

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