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We monitored ROS production, modifications in mitochondrial area and respiratory parameters from macrophages following sUA stimulus and observed that sUA is released in a hypoxic environment and, when the first signal of inflammasome activation is present, is able to trigger NLRP3 through the production of mitochondrial ROS

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The pattern of G6PD mutations, whereby null mutations (such as nonsense mutations, frameshifts, or large deletions) are conspicuously absent, is in striking contrast to that seen in other inherited disorders, such as the thalassemias, hemophilia, and muscular dystrophy

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