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Matuuf and colleagues (2025) reported that primary sensory neurons naturally synthesize AM404

Improvement in wound healing were seen in normoglycemic mice, suggesting a role independent of glucose control and in-vitro studies have shown that GLP-1RAs may directly improve wound healing, independent of blood glucose control, through the reduction of CRP and MMP-9/TIMP-1 ratio, endothelial protection and angiogenesis secondary to increased AMPK, increased endothelial cell proliferation due to stimulation of CD31+ cells, P13/AKT induced keratinocyte migration, increased vascularity and dermal and epidermal regeneration due to increased phosphorylated eNOS and VEGF R2, as well as increased endothelial progenitor cells, fibroblasts, and myofibroblasts

Currently, the vast majority of the evidence on GLP-1 RAs stemmed from case reports with dulaglutide, liraglutide, and semaglutide [72,73,74,75]

Chickpea-resistant starch exhibits bioactive function for alleviating atopic dermatitis via regulating butyrate production