Human Atp-binding Cassette Sub-family G Member 8, ABCG8 ELISA Kit, 96T 3D Cell Culture Consumables There are several related pseudogenes

There are several related pseudogenes on chromosome 7

The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled| a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin

The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2| and expression of this gene may play a role in malignant transformation

These apparently intronless genes encode a 7-transmembrane receptor protein

Human Atp-binding Cassette Sub-family G Member 8, ABCG8 ELISA Kit, 96T 3D Cell Culture Consumables There are several related pseudogenesABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+) and ATP dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed: 11099417, PubMed: 11452359, PubMed: 27144356, PubMed: 15054092). Required for normal sterol homeostasis (PubMed: 11099417, PubMed: 11452359, PubMed: