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127,128,129,130 The resulting glutathione persulphide is a substrate for either persulphide dioxygenase, which oxidises the sulphane sulphur yielding sulphite and glutathione, or rhodanese, which generates thiosulphate

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The acquisition of these and other transition metals is essential for the survival of the pathogen in host tissues, and during bacterial infection, a battle ensues between the pathogen and the host: the host responds to the pathogen by limiting the availability of metals, as part of an innate immunity strategy called nutritional immunity and the pathogen attempts to counter this maneuver by all means