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This can be interpreted as a surrogate for the compounds on-target activity (Fig

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This review explores the role of SAMe in cancer establishment and development, as well as its potential as a biomarker and therapeutic target.Overview of S-Adenosylmethionine Synthesis Focusing on mammals, although being synthesized in all cells, liver is the organ where most SAMe is produced, accounting for about 85% of transmethylation reactions and 50% of methionine metabolism [4,5]