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Standard 100-130 angstrom silica C18 columns produce poor peak shape and inadequate separation of related impurities for lipidated GLP-1 analogs

This report describes a case of epiploic appendagitis occurring in temporal association with substantial and relatively rapid weight reduction during treatment with tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

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