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Concurrently, moderate levels of ROS serve as critical secondary messengers that activate key pro-survival and proliferative signaling pathways including MAPK, PI3K/AKT, NF-B, and HIF-1

Jean Singh 1

Springer Science + Business Media, LLC., New York, NY, pp 187196 Alvarez-Garcia O, Rogers NH, Smith RG, Lotz MK (2014) Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1