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If irritation is persistent or severe, reducing dose or frequency may help

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In addition to its lack of activity, the mutant p53 protein tends to unfold and aggregate, inducing the formation of amyloid aggregates

Endocrinol Nutr 59(3):197206 Devoto F, Zapparoli L, Bonandrini R, Berlingeri M, Ferrulli A, Luzi L et al (2018) Hungry brains: a meta-analytical review of brain activation imaging studies on food perception and appetite in obese individuals