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In Kansas, where tadpoles do not typically overwinter, the larval period is about 3 mo (Collins, 1993)

[6] Preclinical studies in animal models suggest that GLP-1 receptor activation may: Promote neuroplasticity and neurogenesis (formation of new neurons) in the hippocampus, a region often showing reduced volume in depression Modulate neurotransmitter systems , particularly dopamine and serotonin pathways involved in mood regulation and reward processing Reduce neuroinflammation , which is increasingly recognised as contributing to depressive disorders Enhance brain-derived neurotrophic factor (BDNF) expression, a protein crucial for neuronal health and resilience Metabolic improvements associated with GLP-1 therapy may also contribute indirectly to mood benefits

On the one hand, GLP-1s may improve fertility, as Dominguez notes

Gastroesophageal reflux disease and its management in patients on semaglutide therapy