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Name: downsides of retatrutide Lilly's shows 28% weight loss, but increased side effects Pros and Cons of Retatrutide:
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In relation to histamine, methylation is required for the HNMT enzyme (which breaks down histamine in the brain) and COMT enzyme (which detoxifies oestrogen in the liver)

2018 May;17(5):7227-7237