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In a 2022 analysis looking at GLP-1 users over 12 to 24 months, around 45 percent had already discontinued treatment at one year and nearly 65 percent by two years, and only a minority achieved at least 5 percent weight loss at each time point

Compared with chemically synthesized drugs, natural product-derived therapeutics offer significant advantages, including superior biocompatibility and functional diversity, attributes shaped by evolutionary optimization through long-term natural selection (Yao et al., 2017)