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6 The popular GLP-1R agonist semaglutide Semaglutide is a long-acting GLP-1R agonist structurally similar to GLP-1 but resistant to proteolytic cleavage [96] and is given as a subcutaneous injection to patients with T2D

Clinical trials demonstrate that maximal HbA1c reduction usually occurs after 36 months of therapy at the target maintenance dose