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27 However, contrary to preclinical findings, human studies indicate that weight loss induced by GLP-1 RAs is primarily due to reduced energy intake rather than increased energy expenditure

The guidelines warn, however, that GLP-1 receptor agonist therapy is not indicated for all patients and should be used with caution in patients with a history of significant gastrointestinal disease, such as a diagnosis of gastroparesis, due to a possible exacerbation of the condition with incretin mimetic therapy

Most studies have relatively short follow-up periods (typically 35 years), and breast cancer can have a long latency period

The good news is that as semaglutide improves glycemic control over time, the diabetes-related UTI risk factors may actually decrease