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Resistance was acquired by growth in stepwise-increasing of FLC or MCFG concentrations

TSHR expression in preadipocyte fibroblasts is upregulated by TSH, TSAbs, and IL-6, activating downstream adenylate cyclase/cAMP and PI3K/pAKT pathways, which drive fibroblast-to-adipocyte differentiation and HA production [288,289,290]