IP3KA Polyclonal Antibody, 20ul Recombinant Protein Expression GCKR is considered a susceptibility

GCKR is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY)

Transcripts at this locus may also undergo A to I editing

the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses

Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli

IP3KA Polyclonal Antibody, 20ul Recombinant Protein Expression GCKR is considered a susceptibilityRegulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5 trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5 trisphosphate 3 kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP dependent